Veterinary advice should be sought before applying any treatment or vaccine.
Equine Malignant Melanoma, Equine Melanocytic Disease
|Xenogenic DNA vaccination||An antigen-specific gene immunotherapy, using a Xenogenic DNA plasmid in the form of several by-weekly injections with a DNA-based vaccine to target an immune response against the melanoma protein tyrosinase. Clinical trials have been conducted on horses at the University of TN showing it to be a safe and well tolerated form of treatment. However it is a high cost treatment, starting at $2500 and up.|
|Cimetidine||A histamine H2-receptor antagonist that as a daily oral supplement, has had mixed results of effectiveness, but has been found in some horses to prolong survival of horses with melanomas, depending on the type and size of the melanomas.|
|Cisplatin||A heavy metal compound that inhibits DNA synthesis. It was reported be 81% effective in cases of early-stage melanomas that were not previously treated. However new tumors continued to develop in other areas of the body. Implanting cisplatin-containing biodegradable beads into the tumor alongside conventional debulking or CO2 laser debulking was found to be successful at resolution of tumors for at least 2 years following treatment.|
|Surgical excision||Report ably the most effective form of treatment for horses with stage 1 or 2 melanomas. However, in a study conducted by Rowe and Sullins in 2004, they discovered close to half of the horses in the study which had their tumors surgically removed ended up having that tumor increase in size or developed more tumors at the same location or elsewhere on the body.|